Medin induces pro‐inflammatory activation of human brain vascular smooth muscle cells

Medin induces pro‐inflammatory activation of human brain vascular smooth muscle cells

Abstract Medin, a common amyloidogenic protein, accumulates in the vasculature with aging. We evaluated the effects of medin on human brain vascular smooth muscle cell (VSMC) activation. VSMCs were exposed to medin (0.5, 1, and 5 μM) without or with the small molecule nuclear factor‐κB (NFκB) inhibi...

Full description

Saved in:
Bibliographic Details
Main Authors: Nina Karamanova, Kaleb T. Morrow, Alana Maerivoet, Jillian Madine, Ming Li, Raymond Q. Migrino
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Physiological Reports
Subjects:
aging
amyloid
inflammation
smooth muscle dysfunction
vascular dementia
Online Access:https://doi.org/10.14814/phy2.70418
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.14814/phy2.70418

Similar Items