Single low dose primaquine to block the transmission of Plasmodium falciparum—proposed stand-alone and ACT-adapted regimens

Single low dose primaquine to block the transmission of Plasmodium falciparum—proposed stand-alone and ACT-adapted regimens

Abstract Background Despite the 2012 WHO recommendation to add single low dose primaquine (SLDPQ, 0.25 mg/kg body weight) to artemisinin-based combination treatments (ACTs) for blocking the transmission of artemisinin-resistant Plasmodium falciparum, there are currently no weight-based regimens foun...

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Main Authors: Walter R. J. Taylor, Peter Olupot-Olupot, Marie A. Onyamboko, Natenapa Chimjinda, Chiraporn Taya, Julie Nguyen Ngoc Pouplin, Thomas N. Williams, Kathryn Maitland, Caterina A. Fanello, Nicholas P. J. Day, Joel Tarning, Nicholas J. White, Mavuto Mukaka
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Medicine
Subjects:
Primaquine
Transmission blocking
Plasmodium falciparum
Allometric dosing
Haemolysis
Glucose-6-phosphate dehydrogenase deficiency
Online Access:https://doi.org/10.1186/s12916-025-04153-4
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https://doi.org/10.1186/s12916-025-04153-4

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