Xanthohumol modulate autophagy and ER stress to counteract stemness and enhance cisplatin efficacy in head and neck squamous cell carcinoma

Xanthohumol modulate autophagy and ER stress to counteract stemness and enhance cisplatin efficacy in head and neck squamous cell carcinoma

Abstract Natural compounds have been increasingly investigated for their efficient anti-cancer activity. Xanthohumol (XN), a flavonoid derived from hops, has shown promise in preclinical studies for various cancers due to its unique biological properties. This study investigates the effects of XN an...

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Bibliographic Details
Main Authors: Vitale Del Vecchio, Ibone Rubio Sanchez-Pajares, Sameer Kumar Panda, Ayesha Rehman, Vincenzo De Falco, Aditya Nigam, Laura Mosca, Diana Russo, Claudia Arena, Maria Maddalena Nicoletti, Vincenzo Desiderio, Gianpaolo Papaccio, Luigi Mele, Luigi Laino
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Xanthohumol
HNSCC
UPR
Cancer stem cells
Endoplasmic reticulum stress
Autophagy
Online Access:https://doi.org/10.1038/s41598-025-98003-1
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https://doi.org/10.1038/s41598-025-98003-1

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