CFTR ion transport deficiency primes the epithelium for partial epithelial-mesenchymal transition in cystic fibrosis

CFTR ion transport deficiency primes the epithelium for partial epithelial-mesenchymal transition in cystic fibrosis

IntroductionCystic fibrosis (CF) is a monogenic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which encodes a Cl−/HCO3− ion channel located at the apical plasma membrane (PM) of epithelial cells. CFTR dysfunction disrupts epithelial barrier integ...

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Bibliographic Details
Main Authors: Cláudia S. Rodrigues, Matilde Canto, Raquel Torres, Violeta Railean, Sofia S. Ramalho, Carlos M. Farinha, Ines Pankonien, Margarida D. Amaral
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Pharmacology
Subjects:
cystic fibrosis
CFTR
P.Phe508del
p.Gly551Asp
epithelial-mesenchymal transition
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1655479/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1655479/full

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