Assessment of the Antibacterial Properties and Cytocompatibility of Implant Coatings Incorporating Antimicrobial Agents: An In vitro Study
Objective: This study evaluates the antibacterial efficacy and cytocompatibility of titanium implants coated with silver, chitosan, and antibiotics. Materials and Methods: Antibacterial properties were tested using inhibition zones against S. aureus, E. coli, and P. aeruginosa. The cytocompatibility...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-12-01
|
| Series: | Journal of Pharmacy and Bioallied Sciences |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jpbs.jpbs_1104_24 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841543536440246272 |
|---|---|
| author | Saloni Verma Annuroopa Mahapatra Kavita Gupta Harisha Dewan Minu Raju D Anupama Prasad |
| author_facet | Saloni Verma Annuroopa Mahapatra Kavita Gupta Harisha Dewan Minu Raju D Anupama Prasad |
| author_sort | Saloni Verma |
| collection | DOAJ |
| description | Objective:
This study evaluates the antibacterial efficacy and cytocompatibility of titanium implants coated with silver, chitosan, and antibiotics.
Materials and Methods:
Antibacterial properties were tested using inhibition zones against S. aureus, E. coli, and P. aeruginosa. The cytocompatibility was assessed through cell viability, adhesion, and proliferation by using human osteoblast-like cells (MG-63). Statistical analysis was performed using ANOVA and Tukey’s HSD test.
Results:
Antibiotics showed the highest antibacterial activity. Silver reduced cell viability, adhesion, and proliferation, while chitosan balanced antibacterial efficacy and biocompatibility. Time-dependent viability assays indicated consistent reduction for silver-treated cells.
Conclusion:
Silver, chitosan, and antibiotics are effective against implant-related pathogens, but their cytocompatibility varies. |
| format | Article |
| id | doaj-art-6077674f711e490fa6dc3dccc490b1cf |
| institution | Kabale University |
| issn | 0976-4879 0975-7406 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj-art-6077674f711e490fa6dc3dccc490b1cf2025-01-13T10:10:12ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0976-48790975-74062024-12-0116Suppl 4S3607S360910.4103/jpbs.jpbs_1104_24Assessment of the Antibacterial Properties and Cytocompatibility of Implant Coatings Incorporating Antimicrobial Agents: An In vitro StudySaloni VermaAnnuroopa MahapatraKavita GuptaHarisha DewanMinu RajuD Anupama PrasadObjective: This study evaluates the antibacterial efficacy and cytocompatibility of titanium implants coated with silver, chitosan, and antibiotics. Materials and Methods: Antibacterial properties were tested using inhibition zones against S. aureus, E. coli, and P. aeruginosa. The cytocompatibility was assessed through cell viability, adhesion, and proliferation by using human osteoblast-like cells (MG-63). Statistical analysis was performed using ANOVA and Tukey’s HSD test. Results: Antibiotics showed the highest antibacterial activity. Silver reduced cell viability, adhesion, and proliferation, while chitosan balanced antibacterial efficacy and biocompatibility. Time-dependent viability assays indicated consistent reduction for silver-treated cells. Conclusion: Silver, chitosan, and antibiotics are effective against implant-related pathogens, but their cytocompatibility varies.https://journals.lww.com/10.4103/jpbs.jpbs_1104_24antibacterial efficacyantibioticsantimicrobial coatingsdental implants |
| spellingShingle | Saloni Verma Annuroopa Mahapatra Kavita Gupta Harisha Dewan Minu Raju D Anupama Prasad Assessment of the Antibacterial Properties and Cytocompatibility of Implant Coatings Incorporating Antimicrobial Agents: An In vitro Study Journal of Pharmacy and Bioallied Sciences antibacterial efficacy antibiotics antimicrobial coatings dental implants |
| title | Assessment of the Antibacterial Properties and Cytocompatibility of Implant Coatings Incorporating Antimicrobial Agents: An In vitro Study |
| title_full | Assessment of the Antibacterial Properties and Cytocompatibility of Implant Coatings Incorporating Antimicrobial Agents: An In vitro Study |
| title_fullStr | Assessment of the Antibacterial Properties and Cytocompatibility of Implant Coatings Incorporating Antimicrobial Agents: An In vitro Study |
| title_full_unstemmed | Assessment of the Antibacterial Properties and Cytocompatibility of Implant Coatings Incorporating Antimicrobial Agents: An In vitro Study |
| title_short | Assessment of the Antibacterial Properties and Cytocompatibility of Implant Coatings Incorporating Antimicrobial Agents: An In vitro Study |
| title_sort | assessment of the antibacterial properties and cytocompatibility of implant coatings incorporating antimicrobial agents an in vitro study |
| topic | antibacterial efficacy antibiotics antimicrobial coatings dental implants |
| url | https://journals.lww.com/10.4103/jpbs.jpbs_1104_24 |
| work_keys_str_mv | AT saloniverma assessmentoftheantibacterialpropertiesandcytocompatibilityofimplantcoatingsincorporatingantimicrobialagentsaninvitrostudy AT annuroopamahapatra assessmentoftheantibacterialpropertiesandcytocompatibilityofimplantcoatingsincorporatingantimicrobialagentsaninvitrostudy AT kavitagupta assessmentoftheantibacterialpropertiesandcytocompatibilityofimplantcoatingsincorporatingantimicrobialagentsaninvitrostudy AT harishadewan assessmentoftheantibacterialpropertiesandcytocompatibilityofimplantcoatingsincorporatingantimicrobialagentsaninvitrostudy AT minuraju assessmentoftheantibacterialpropertiesandcytocompatibilityofimplantcoatingsincorporatingantimicrobialagentsaninvitrostudy AT danupamaprasad assessmentoftheantibacterialpropertiesandcytocompatibilityofimplantcoatingsincorporatingantimicrobialagentsaninvitrostudy |