Assessment of the Antibacterial Properties and Cytocompatibility of Implant Coatings Incorporating Antimicrobial Agents: An In vitro Study
Objective: This study evaluates the antibacterial efficacy and cytocompatibility of titanium implants coated with silver, chitosan, and antibiotics. Materials and Methods: Antibacterial properties were tested using inhibition zones against S. aureus, E. coli, and P. aeruginosa. The cytocompatibility...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jpbs.jpbs_1104_24 |
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| Summary: | Objective:
This study evaluates the antibacterial efficacy and cytocompatibility of titanium implants coated with silver, chitosan, and antibiotics.
Materials and Methods:
Antibacterial properties were tested using inhibition zones against S. aureus, E. coli, and P. aeruginosa. The cytocompatibility was assessed through cell viability, adhesion, and proliferation by using human osteoblast-like cells (MG-63). Statistical analysis was performed using ANOVA and Tukey’s HSD test.
Results:
Antibiotics showed the highest antibacterial activity. Silver reduced cell viability, adhesion, and proliferation, while chitosan balanced antibacterial efficacy and biocompatibility. Time-dependent viability assays indicated consistent reduction for silver-treated cells.
Conclusion:
Silver, chitosan, and antibiotics are effective against implant-related pathogens, but their cytocompatibility varies. |
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| ISSN: | 0976-4879 0975-7406 |