PRRSV GP4 subunit vaccine combined with adenovirus heterologous prime-boost immunization strategy induced a significant immune response in mice

PRRSV GP4 subunit vaccine combined with adenovirus heterologous prime-boost immunization strategy induced a significant immune response in mice

Abstract Background The porcine reproductive and respiratory syndrome virus (PRRSV) continues to cause widespread infections in the pig industry worldwide. Currently, multiple PRRSV vaccine candidates are in preclinical or clinical trials, and each has different advantages and limitations. Glycoprot...

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Main Authors: Honghuan Li, Wenxiang Zhang, Wenxing Wang, Yanjie Qiao, Mingguo Xu, Ziwei Liu, Xiaoxiao Gu, Aodi Wu, Zhongchen Ma, Chuangfu Chen, Wei Zhang
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Veterinary Research
Subjects:
PRRSV
Glycoprotein 4
Subunit vaccine
Adenovirus
Heterologous prime-boost immunization strategy
Vaccine
Online Access:https://doi.org/10.1186/s12917-025-04842-5
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https://doi.org/10.1186/s12917-025-04842-5

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