Glucagon and Glucose Availability Influence Metabolic Heterogeneity and Malignancy in Pancreatic Neuroendocrine Tumour (pNET) Cells: Novel Routes for Therapeutic Targeting

Glucagon and Glucose Availability Influence Metabolic Heterogeneity and Malignancy in Pancreatic Neuroendocrine Tumour (pNET) Cells: Novel Routes for Therapeutic Targeting

Cancer metabolism is a hallmark of cancer. However, the impact of systemic metabolism and diet on tumour evolution is less understood. This study delves into the role of glucagon, as a component of the pancreatic microenvironment, in regulating features of pancreatic neuroendocrine tumour (pNET) cel...

Full description

Saved in:
Bibliographic Details
Main Authors: Bárbara Ferreira, Isabel Lemos, Cindy Mendes, Beatriz Chumbinho, Fernanda Silva, Daniela Pereira, Emanuel Vigia, Luís G. Gonçalves, António Figueiredo, Daniela Cavaco, Jacinta Serpa
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Molecules
Subjects:
glucagon
pancreatic neuroendocrine tumours (pNETs)
cancer metabolism
biomarkers
glucagon receptor (GCGR)
glucagon-like peptide-1 receptor (GLP-1R)
Online Access:https://www.mdpi.com/1420-3049/30/13/2736
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://www.mdpi.com/1420-3049/30/13/2736

Similar Items