Effects of Angiotensin II Receptor 1 Inhibition by LCZ696 on the Acquisition and Relapse of Methamphetamine-Associated Contextual Memory

Effects of Angiotensin II Receptor 1 Inhibition by LCZ696 on the Acquisition and Relapse of Methamphetamine-Associated Contextual Memory

<b>Background/Objectives:</b> Contextual memory associated with methamphetamine (METH) use contributes to relapse and persistence of addiction. Angiotensin II type 1 receptor (AT1R) signaling has been implicated in drug reinforcement. LCZ696, a clinically used combination of sacubitril (...

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Main Authors: Xiaofang Li, Zhiting Zou, Xiangdong Yang, Jinnan Lü, Xiaoyu Zhang, Jiahui Zhou, Dan Zhu, Xinshuang Gong, Shujun Lin, Zhaoying Yu, Zizhen Si, Wenting Wei, Yakai Xie, Yu Liu
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Pharmaceuticals
Subjects:
methamphetamine
rewarding effect
LCZ696
angiotensin II type I receptor II I
Creb
Online Access:https://www.mdpi.com/1424-8247/18/7/1016
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https://www.mdpi.com/1424-8247/18/7/1016

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