Reduced mtDNA Copy Number Links to Vascular Calcification and Restores After Transplantation

Reduced mtDNA Copy Number Links to Vascular Calcification and Restores After Transplantation

Patients with chronic kidney disease (CKD) face an increased risk of early vascular aging, progressive vascular calcification, and premature death. With increasing age, mitochondrial function and mitochondrial DNA copy number (mtDNA-cn) decline. This has been identified as an independent predictor o...

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Bibliographic Details
Main Authors: Angelina Schwarz, Abdul Rashid Qureshi, Leah Hernandez, Lars Wennberg, Annika Wernerson, Karolina Kublickiene, Paul G. Shiels, Roberta Filograna, Peter Stenvinkel, Anna Witasp
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Cells
Subjects:
CKD
early vascular calcification
mtDNA copy number
renal transplantation
CAC score
Online Access:https://www.mdpi.com/2073-4409/14/12/917
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