Investigating the mechanism of inositol against paclitaxel chemoresistance on triple-negative breast cancer by using 7T multiparametric MRI and mitochondrial changes

Investigating the mechanism of inositol against paclitaxel chemoresistance on triple-negative breast cancer by using 7T multiparametric MRI and mitochondrial changes

Abstract Background The emerging triple-negative breast cancer (TNBC) treatments target mitochondrial fission to combat paclitaxel (PTX) resistance. Inositol’s inhibition of this process makes it a potential therapy. Multiparametric MRI provides an early and effective assessment of these innovations...

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Bibliographic Details
Main Authors: Wentao Xuan, Wangmin Li, Lixin Ke, Yuanyu Shen, Xiaolei Zhang, Yue Chen, Zhiliang Ye, Caiyu Zhuang, Shiyan Xie, Renhua Wu, Yan Lin
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Breast Cancer Research
Subjects:
Triple-negative breast cancer
Paclitaxel resistance
Mitochondrial dynamics
Inositol
Multiparametric MRI
Online Access:https://doi.org/10.1186/s13058-025-02051-4
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https://doi.org/10.1186/s13058-025-02051-4

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