Mechanistic Insights into the Mutational Landscape of the Main Protease/3CLPro and Its Impact on Long-Term COVID-19/SARS-CoV-2 Management

Mechanistic Insights into the Mutational Landscape of the Main Protease/3CLPro and Its Impact on Long-Term COVID-19/SARS-CoV-2 Management

The main proteinase (Mpro), or 3CLpro, is a critical enzyme in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lifecycle and is responsible for breaking down and releasing vital functional viral proteins crucial for virus development and transmission. As a catalytically active dimer...

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Main Authors: Aganze Gloire-Aimé Mushebenge, Samuel Chima Ugbaja, Nonjabulo Ntombikhona Magwaza, Nonkululeko Avril Mbatha, Tambwe Willy Muzumbukilwa, Mukanda Gedeon Kadima, Fave Yohanna Tata, Mthokosizi Bongani Nxumalo, Riziki Ghislain Manimani, Ntabaza Ndage, Bakari Salvius Amuri, Kahumba Byanga, Manimbulu Nlooto, Rene B. Khan, Hezekiel M. Kumalo
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Future Pharmacology
Subjects:
SARS-CoV-2
main protease/3CLPro
mutations
vaccine efficacy
enzymatic activity
therapeutic targeting
Online Access:https://www.mdpi.com/2673-9879/4/4/44
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