IL-23 promotes neuronal ferroptosis via IL-23R/STAT3 signaling after traumatic brain injury

IL-23 promotes neuronal ferroptosis via IL-23R/STAT3 signaling after traumatic brain injury

Abstract Background Traumatic brain injury (TBI) causes significant neuronal death, but the underlying mechanisms remain poorly understood. The role of interleukin-23 (IL-23) signaling in post-traumatic neuronal injury requires investigation. Methods We examined IL-23 levels in clinical samples from...

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Main Authors: Bo Chen, Guihong Shi, Jianye Xu, Xu Zhang, Yanlin Zhu, Lei Li, Cong Wang, Dilmurat Gheyret, Jinchao Wang, Xilei Liu, Yiyao Cao, Rui Tan, Yuan Zhou, RongCai Jiang, Shenghui Li, Tuo Li, Xiao Liu, Xin Chen, Guili Yang, Jianning Zhang, Shu Zhang
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Cell Communication and Signaling
Subjects:
IL-23/IL-23R signaling
Ferroptosis
Neuron-macrophage interaction
Traumatic brain injury
Therapeutic targeting
Online Access:https://doi.org/10.1186/s12964-025-02319-4
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https://doi.org/10.1186/s12964-025-02319-4

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