Hyperbaric oxygen treatment attenuates naloxone-precipitated opioid withdrawal behaviors and alters microglial activity in male and female mice

Hyperbaric oxygen treatment attenuates naloxone-precipitated opioid withdrawal behaviors and alters microglial activity in male and female mice

Abstract Opioid use disorder poses a complex challenge marked by high relapse rates, which stem from an intricate interplay between physical dependence and psychological vulnerabilities. Previous research has demonstrated that hyperbaric oxygen treatment (HBOT), exposure to 100% oxygen under elevate...

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Main Authors: Meg T. Southard, Giuseppe Giannotti, Amit Thakar, Trinity R. Willsey, Lydia G. Bailey, Frank Salazar, Shane Hentges, Raymond M. Quock, Travis E. Brown
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-07937-z
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https://doi.org/10.1038/s41598-025-07937-z

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