ATF3-mediated inhibition of Trem2 by Toxoplasma gondii contributes to adverse pregnancy outcomes

ATF3-mediated inhibition of Trem2 by Toxoplasma gondii contributes to adverse pregnancy outcomes

Abstract Background Approximately one in three people worldwide have been exposed to Toxoplasma gondii (T. gondii). Primary infection with T. gondii during pregnancy can cause severe complications. Our previous study demonstrated that deficiency of triggering receptor expressed on myeloid cells 2 (T...

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Bibliographic Details
Main Authors: Xiaoyu Geng, Tiankun Yao, Xinyue Wang, Jianan Wang, Tongrui Zhang, Tianmei Qian, Chun Liu, Jinling Chen
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Parasites & Vectors
Subjects:
Toxoplasma gondii
Adverse pregnancy outcomes
Macrophages
Trem2 promoter
ATF3
Online Access:https://doi.org/10.1186/s13071-025-06894-w
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https://doi.org/10.1186/s13071-025-06894-w

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