Efficacy of systemic temozolomide‐activated phage‐targeted gene therapy in human glioblastoma

Efficacy of systemic temozolomide‐activated phage‐targeted gene therapy in human glioblastoma

Abstract Glioblastoma multiforme (GBM) is the most lethal primary intracranial malignant neoplasm in adults and most resistant to treatment. Integration of gene therapy and chemotherapy, chemovirotherapy, has the potential to improve treatment. We have introduced an intravenous bacteriophage (phage)...

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Main Authors: Justyna Magdalena Przystal, Sajee Waramit, Md Zahidul Islam Pranjol, Wenqing Yan, Grace Chu, Aitthiphon Chongchai, Gargi Samarth, Nagore Gene Olaciregui, Ghazaleh Tabatabai, Angel Montero Carcaboso, Eric Ofori Aboagye, Keittisak Suwan, Amin Hajitou
Format: Article
Language:English
Published: Springer Nature 2019-02-01
Series:EMBO Molecular Medicine
Subjects:
bacteriophage
glioblastoma
Grp78
targeting
temozolomide
Online Access:https://doi.org/10.15252/emmm.201708492
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https://doi.org/10.15252/emmm.201708492

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