Androgens drive SLC1A5-dependent metabolic reprogramming in polycystic ovary syndrome

Androgens drive SLC1A5-dependent metabolic reprogramming in polycystic ovary syndrome

Abstract Polycystic ovary syndrome is the primary cause of female infertility. Growing evidence suggests that dysregulation of amino acid metabolism plays a significant role in the onset and progression. However, the underlying mechanism remains unclear. In this study, we conduct targeted metabolite...

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Main Authors: Yishu Wang, Jiaying Wu, Gaochen Zhang, Yan Shi, Yicong Meng, Pingping Lv, Weiwei Huang, Yunfei Su, Zhiyang Zhou, Bo Wang, Xiaojun Chen, Chengliang Zhou, Jiexue Pan, Li Jin, Xiaotao Wang, Yanting Wu, Jianzhong Sheng, Xinmei Liu, Yu Zhang, Guolian Ding, Chuanjin Yu, Hefeng Huang
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62951-z
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https://doi.org/10.1038/s41467-025-62951-z

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