ATP/P2X7 receptor/NLRP3 pathway facilitates renal tubular epithelial-myofibroblast transdifferentiation and interstitial fibrosis in rats with unilateral ureteral obstruction

ATP/P2X7 receptor/NLRP3 pathway facilitates renal tubular epithelial-myofibroblast transdifferentiation and interstitial fibrosis in rats with unilateral ureteral obstruction

BackgroundP2X7 receptor (P2X7R) is reported involved in renal fibrosis and the activation of NOD-like receptor protein 3 (NLRP3) inflammasome. This study aimed to investigate the role of the P2X7R and NLRP3 in renal tubular epithelial-myofibroblast transdifferentiation (TEMT) and interstitial fibros...

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Bibliographic Details
Main Authors: Hui Tan, Feiyan Li, Yanchao Cui, Ziwen Li, Shiqiang Yan, Quanfeng Deng
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Pharmacology
Subjects:
P2X7 receptor
NLRP3
renal interstitial fibrosis
ATP
tubular epithelial-myofibroblast transdifferentiation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1598151/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1598151/full

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