Elucidating the integrative role and possible molecular mechanisms of Salvia miltiorrhiza ingredients and gut microbiota-derived metabolites in alleviating pyroptosis-mediated hepatic ischemia–reperfusion injury through network pharmacology

Elucidating the integrative role and possible molecular mechanisms of Salvia miltiorrhiza ingredients and gut microbiota-derived metabolites in alleviating pyroptosis-mediated hepatic ischemia–reperfusion injury through network pharmacology

Currently, therapeutic options for hepatic ischemia–reperfusion injury (HIRI) remain limited and challenging. An emerging alternative involves the combination of ingredients from traditional Chinese medicine (TCM) and beneficial gut microbiota (GM) metabolites. This study integrates ingredients of S...

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Bibliographic Details
Main Authors: Rujia Wang, Danhong Yang, Yi Chen, Jiabing Wang
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Artificial Cells, Nanomedicine, and Biotechnology
Subjects:
Hepatic ischemia–reperfusion injury
Salvia miltiorrhiza
gut microbiota
network pharmacology
miRNAs
Online Access:https://www.tandfonline.com/doi/10.1080/21691401.2025.2547646
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https://www.tandfonline.com/doi/10.1080/21691401.2025.2547646

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