Brain endothelial permeability, transport, and flow assessed over 10 orders of magnitude using the in situ brain perfusion technique

Brain endothelial permeability, transport, and flow assessed over 10 orders of magnitude using the in situ brain perfusion technique

Abstract Background Cerebral blood flow normally places a limit on the magnitude of brain vascular permeability (P) that can be measured in vivo. At normal cerebral blood flow, this limit falls at the lower end of lipophilicity for most FDA-approved CNS drugs. In this study, we report on two methods...

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Main Authors: Quentin R. Smith, Haritha Mandula, Jagan Mohan R. Parepally, Jun Oki, Fancy Thomas, Helen R. Thorsheim, Abraham J. Al-Ahmad, Thomas J. Abbruscato, Per Ask, David S. Hage, Peter J. Robinson
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Fluids and Barriers of the CNS
Subjects:
Blood brain barrier
Enhanced dissociation
Pharmaceutical screening
Diazepam
Albumin
Alpha-1 acid glycoprotein
Online Access:https://doi.org/10.1186/s12987-024-00584-y
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https://doi.org/10.1186/s12987-024-00584-y

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