Computational modeling of ketamine-induced changes in gamma-band oscillations: The contribution of parvalbumin and somatostatin interneurons.

Ketamine, an NMDA receptor (NMDA-R) antagonist, produces psychotomimetic effects when administered in sub-anesthetic dosages. While previous research suggests that Ketamine alters the excitation/inhibition (E/I)-balance in cortical microcircuits, the precise neural mechanisms by which Ketamine produ...

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Bibliographic Details
Main Authors: Jessie Rademacher, Tineke Grent-'t-Jong, Davide Rivolta, Andreas Sauer, Bertram Scheller, Guillermo Gonzalez-Burgos, Christoph Metzner, Peter J Uhlhaas
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-06-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1013118
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