Co-expression of a truncated TGFβ receptor II in c-Met CAR T cells enhances antitumor activity against lung adenocarcinoma

Co-expression of a truncated TGFβ receptor II in c-Met CAR T cells enhances antitumor activity against lung adenocarcinoma

Abstract This study investigates the therapeutic potential of c-Met-targeted CAR T cells co-expressing a truncated TGFβ receptor II (TGFBR2-N) to overcome TGFβ1-mediated immunosuppression in lung adenocarcinoma. Bioinformatics analysis using the GEPIA2 database and single-cell RNA sequencing (scRNA-...

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Bibliographic Details
Main Authors: Chao Su, Wenbin Hu, Huafang Mao
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Lung cancer
Chimeric antigen receptor
T cell
TGF-β
Online Access:https://doi.org/10.1038/s41598-025-15086-6
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https://doi.org/10.1038/s41598-025-15086-6

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