Study of Lophomonas blattarum Infection in Kidney Transplant Patients in Mashhad City, Iran
Background. Lophomonas blattarum is a flagellate protozoan which is known as an emerging parasite in the human respiratory system. Organ transplant recipients are considered as immunocompromised patients due to prescription of immunosuppressive drugs. This group of patients is susceptible to opportu...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Interdisciplinary Perspectives on Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2020/6631224 |
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| author | Zahra Gheisari Fariba Berenji Fatemeh Nazemian Seyed Ali Akbar Shamsian Lida Jarahi Mahmoud Parian Bibi Razieh Hosseini Farash Ghodratollah Salehi Sangani |
| author_facet | Zahra Gheisari Fariba Berenji Fatemeh Nazemian Seyed Ali Akbar Shamsian Lida Jarahi Mahmoud Parian Bibi Razieh Hosseini Farash Ghodratollah Salehi Sangani |
| author_sort | Zahra Gheisari |
| collection | DOAJ |
| description | Background. Lophomonas blattarum is a flagellate protozoan which is known as an emerging parasite in the human respiratory system. Organ transplant recipients are considered as immunocompromised patients due to prescription of immunosuppressive drugs. This group of patients is susceptible to opportunistic infection as well as lophomoniasis. This study aims to investigate the prevalence and clinical manifestation of pulmonary infections caused by L. blattarum in kidney transplant recipients. Methods. This is a case-control study including 50 kidney transplant recipients and 50 controls. The sputum samples were collected from 50 kidney transplant recipients with bronchopulmonary infection signs suspected to lophomoniasis admitted in Montaserieh and Imam Reza hospitals, Mashhad, Iran. 50 healthy individuals as the control group were matched for sex and age with case ones. The consent form, checklist, and required information were provided for each patient. All samples were microscopically examined for the flagellated protozoan, L. blattarum, using direct smear. Results. Among 50 kidney transplant recipients suspected to lophomoniasis, L. blattarum was identified in sputum samples of 4 (8%) participants of the case group including one female and three males. None of the samples were positive among the control group. Symptoms in patients of this study were high fever (4 out of 4 patients), cough (3 out of 4 patients), and dyspnea (2 out of 4 patients). Three patients showed a positive response to metronidazole treatment. Conclusion. The results of this study suggest that L. blattarum should be considered as a pathogenic agent in kidney transplant recipients. It is necessary to examine sputum samples in posttransplant pneumonia patients, especially in those resistant to antibacterial therapy. |
| format | Article |
| id | doaj-art-5fdc495ac7a445b2a5d0e350d7f35e66 |
| institution | Kabale University |
| issn | 1687-708X 1687-7098 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Interdisciplinary Perspectives on Infectious Diseases |
| spelling | doaj-art-5fdc495ac7a445b2a5d0e350d7f35e662025-02-03T06:43:42ZengWileyInterdisciplinary Perspectives on Infectious Diseases1687-708X1687-70982020-01-01202010.1155/2020/66312246631224Study of Lophomonas blattarum Infection in Kidney Transplant Patients in Mashhad City, IranZahra Gheisari0Fariba Berenji1Fatemeh Nazemian2Seyed Ali Akbar Shamsian3Lida Jarahi4Mahmoud Parian5Bibi Razieh Hosseini Farash6Ghodratollah Salehi Sangani7Department of Parasitology and Mycology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Parasitology and Mycology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Nephrology, Emam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Parasitology and Mycology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Community Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Parasitology and Mycology, Emam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Parasitology and Mycology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Parasitology and Mycology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranBackground. Lophomonas blattarum is a flagellate protozoan which is known as an emerging parasite in the human respiratory system. Organ transplant recipients are considered as immunocompromised patients due to prescription of immunosuppressive drugs. This group of patients is susceptible to opportunistic infection as well as lophomoniasis. This study aims to investigate the prevalence and clinical manifestation of pulmonary infections caused by L. blattarum in kidney transplant recipients. Methods. This is a case-control study including 50 kidney transplant recipients and 50 controls. The sputum samples were collected from 50 kidney transplant recipients with bronchopulmonary infection signs suspected to lophomoniasis admitted in Montaserieh and Imam Reza hospitals, Mashhad, Iran. 50 healthy individuals as the control group were matched for sex and age with case ones. The consent form, checklist, and required information were provided for each patient. All samples were microscopically examined for the flagellated protozoan, L. blattarum, using direct smear. Results. Among 50 kidney transplant recipients suspected to lophomoniasis, L. blattarum was identified in sputum samples of 4 (8%) participants of the case group including one female and three males. None of the samples were positive among the control group. Symptoms in patients of this study were high fever (4 out of 4 patients), cough (3 out of 4 patients), and dyspnea (2 out of 4 patients). Three patients showed a positive response to metronidazole treatment. Conclusion. The results of this study suggest that L. blattarum should be considered as a pathogenic agent in kidney transplant recipients. It is necessary to examine sputum samples in posttransplant pneumonia patients, especially in those resistant to antibacterial therapy.http://dx.doi.org/10.1155/2020/6631224 |
| spellingShingle | Zahra Gheisari Fariba Berenji Fatemeh Nazemian Seyed Ali Akbar Shamsian Lida Jarahi Mahmoud Parian Bibi Razieh Hosseini Farash Ghodratollah Salehi Sangani Study of Lophomonas blattarum Infection in Kidney Transplant Patients in Mashhad City, Iran Interdisciplinary Perspectives on Infectious Diseases |
| title | Study of Lophomonas blattarum Infection in Kidney Transplant Patients in Mashhad City, Iran |
| title_full | Study of Lophomonas blattarum Infection in Kidney Transplant Patients in Mashhad City, Iran |
| title_fullStr | Study of Lophomonas blattarum Infection in Kidney Transplant Patients in Mashhad City, Iran |
| title_full_unstemmed | Study of Lophomonas blattarum Infection in Kidney Transplant Patients in Mashhad City, Iran |
| title_short | Study of Lophomonas blattarum Infection in Kidney Transplant Patients in Mashhad City, Iran |
| title_sort | study of lophomonas blattarum infection in kidney transplant patients in mashhad city iran |
| url | http://dx.doi.org/10.1155/2020/6631224 |
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