Analysis of the efficacy of avatrombopag for the delayed platelet engraftment after allogeneic hematopoietic stem cell transplantation for aplastic anemia

Analysis of the efficacy of avatrombopag for the delayed platelet engraftment after allogeneic hematopoietic stem cell transplantation for aplastic anemia

BackgroundDelayed platelet engraftment (DPE) after allo-HSCT lacks standard therapy. Avatrombopag (AVA), a second-generation TPO agonist, is often delayed until transfusion-related events occur, potentially harming high-risk recipients.ObjectivesWe compared recombinant human thrombopoietin (rh-TPO)...

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Main Authors: Xinhe Zhang, Jia Feng, Zhengwei Tan, Herui Zhang, Huijin Hu, Yuechao Zhao, Dijiong Wu, Yu Zhang, Liqiang Wu, Tonglin Hu, Zhengsong Yan, Baodong Ye, Wenbin Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Medicine
Subjects:
DPE
avatrombopag
Allo-HSCT
TPO-RA
RhTPO
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2025.1626325/full
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https://www.frontiersin.org/articles/10.3389/fmed.2025.1626325/full

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