Dextromethorphan-induced serotonin syndrome leading to rhabdomyolysis and dialysis-requiring acute kidney injury: a case report and review

Dextromethorphan-induced serotonin syndrome leading to rhabdomyolysis and dialysis-requiring acute kidney injury: a case report and review

Abstract Background Dextromethorphan (DXM) misuse, particularly among young individuals, has risen owing to its euphoric and hallucinogenic effects. High-dose DXM ingestion can trigger serotonin syndrome, a condition characterized by psychiatric, neuromuscular, and autonomic symptoms. In severe case...

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Main Authors: Kazuhiro Okamoto, Nobuhiro Hashimoto, Kaiya Ishizeki, Takamichi Nishimura, Shuzo Makino, Akito Takashima, Hiromitsu Miyakawa, Yoshiyasu Ueda, Terumasa Hayashi
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Renal Replacement Therapy
Subjects:
Dextromethorphan
Serotonin syndrome
Rhabdomyolysis
Acute kidney injury
Kidney replacement therapy
Online Access:https://doi.org/10.1186/s41100-025-00616-9
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https://doi.org/10.1186/s41100-025-00616-9

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