Specific sDMA modifications on the RGG/RG motif of METTL14 regulate its function in AML

Specific sDMA modifications on the RGG/RG motif of METTL14 regulate its function in AML

Abstract Background Protein arginine methylations are crucial post-translational modifications (PTMs) in eukaryotes, playing a significant regulatory role in diverse biological processes. Here, we present our investigation into the detailed arginine methylation pattern of the C-terminal RG-rich regi...

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Bibliographic Details
Main Authors: Yulun Zhong, Rou Zhang, Lingzi Lu, Huijian Tan, Yuyu You, Yang Mao, Yanqiu Yuan
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Cell Communication and Signaling
Subjects:
METTL14
Symmetric dimethylarginine
N6-methyladenosine
Post-translational modification
Acute myeloid leukemia
Online Access:https://doi.org/10.1186/s12964-025-02130-1
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https://doi.org/10.1186/s12964-025-02130-1

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