Supersaturated Liquid Formulation of Pazopanib Hydrochloride Loaded with Synergistic Precipitation Inhibitors

Supersaturated Liquid Formulation of Pazopanib Hydrochloride Loaded with Synergistic Precipitation Inhibitors

This study aimed to develop a supersaturated liquid formulation (SSLF) to enhance the solubility and dissolution of pazopanib hydrochloride (PZH). SSLFs were prepared by a simple stirring method in a heated silicon oil bath (70 °C). PZH showed highly pH-dependent solubility (pH 1.2 > water >&g...

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Bibliographic Details
Main Authors: Jin Woo Park, Sa-Won Lee, Jun Hak Lee, Jun-Pil Jee, Han-Joo Maeng, Dong-Jin Jang, Kwan Hyung Cho
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Molecules
Subjects:
pazopanib hydrochloride
supersaturated formulation
precipitation inhibitor
dissolution
solubility
Online Access:https://www.mdpi.com/1420-3049/29/22/5267
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