A novel role for nonactin: interfering with G-quadruplex in RET-driven medullary thyroid cancer

A novel role for nonactin: interfering with G-quadruplex in RET-driven medullary thyroid cancer

Abstract Background Medullary Thyroid Carcinoma (MTC) is closely associated with mutations in the RET proto-oncogene, placing the activated RET protein at the center of MTC pathogenesis. Existing therapeutic solutions, primarily tyrosine kinase inhibitors such as selpercatinib, vandetanib, and caboz...

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Bibliographic Details
Main Authors: Tariq Alqahtani, Arwa Alsubait, Meshari Aloumi, Abdulrahman Alamer, Ghala Alomari, Osama I. Alwassil, Ahmad J. Obaidullah, Sahar S. Alghamdi
Format: Article
Language:English
Published: BMC 2024-12-01
Series:BMC Cancer
Subjects:
Medullary thyroid carcinoma
Nonactin
RET
G-quadruplex
Drug design
Online Access:https://doi.org/10.1186/s12885-024-13345-9
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