Am80‐GCSF synergizes myeloid expansion and differentiation to generate functional neutrophils that reduce neutropenia‐associated infection and mortality

Am80‐GCSF synergizes myeloid expansion and differentiation to generate functional neutrophils that reduce neutropenia‐associated infection and mortality

Abstract Neutrophils generated by granulocyte colony‐stimulating factor (GCSF) are functionally immature and, consequently, cannot effectively reduce infection and infection‐related mortality in cancer chemotherapy‐induced neutropenia (CCIN). Am80, a retinoic acid (RA) agonist that enhances granuloc...

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Main Authors: Lin Li, Xiaotian Qi, Weili Sun, Hisham Abdel‐Azim, Siyue Lou, Hong Zhu, Nemani V Prasadarao, Alice Zhou, Hiroyuki Shimada, Koichi Shudo, Yong‐Mi Kim, Sajad Khazal, Qiaojun He, David Warburton, Lingtao Wu
Format: Article
Language:English
Published: Springer Nature 2016-10-01
Series:EMBO Molecular Medicine
Subjects:
functional neutrophils
innate immunity
myeloid expansion
neutrophil bactericidal activity
neutrophil differentiation
Online Access:https://doi.org/10.15252/emmm.201606434
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https://doi.org/10.15252/emmm.201606434

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