The Cullin3–Ring E3 ubiquitin ligase complex and USP14 regulate spastin-mediated microtubule severing and promotion of neurite outgrowth

The Cullin3–Ring E3 ubiquitin ligase complex and USP14 regulate spastin-mediated microtubule severing and promotion of neurite outgrowth

Post-translational modification of spastin enables precise spatiotemporal control of its microtubule severing activity. However, the detailed mechanism by which spastin turnover is regulated in the context of neurite outgrowth remains unknown. Here, we found that spastin interacted with ubiquitin an...

Full description

Saved in:
Bibliographic Details
Main Authors: Zhenbin Cai, Hui Wu, Tao Jiang, Ao Ma, Zhichao Meng, Jiehao Zhu, Hongsheng Lin, Yaozhong Liang, Guowei Zhang, Minghui Tan
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2026-04-01
Series:Neural Regeneration Research
Subjects:
cullin3
microtubule severing
neurite outgrowth
protein degradation
spastin
ubiquitination
usp14
Online Access:https://journals.lww.com/10.4103/NRR.NRR-D-25-00037
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://journals.lww.com/10.4103/NRR.NRR-D-25-00037

Similar Items