Contribution of Genetic Factors to Sjögren’s Syndrome and Sjögren’s Syndrome Related Lymphomagenesis
We aimed to summarize the current evidence related to the contributory role of genetic factors in the pathogenesis of Sjögren’s syndrome (SS) and SS-related lymphoma. Genes within the major histocompatibility complex (MHC) locus previously considered conferring increased susceptibility to SS develop...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2015/754825 |
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| _version_ | 1832558530955051008 |
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| author | Adrianos Nezos Clio P. Mavragani |
| author_facet | Adrianos Nezos Clio P. Mavragani |
| author_sort | Adrianos Nezos |
| collection | DOAJ |
| description | We aimed to summarize the current evidence related to the contributory role of genetic factors in the pathogenesis of Sjögren’s syndrome (SS) and SS-related lymphoma. Genes within the major histocompatibility complex (MHC) locus previously considered conferring increased susceptibility to SS development have been also revealed as important contributors in recent genome wide association studies. Moreover, genetic variations outside the MHC locus involving genes in type I interferon pathway, NF-κB signaling, B- and T-cell function and methylation processes have been shown to be associated with both SS and SS-related lymphoma development. Appreciating the functional implications of SS-related genetic variants could provide further insights into our understanding of SS heterogeneity, allowing the design of tailored therapeutic interventions. |
| format | Article |
| id | doaj-art-5f96747d50fb4ce6b79dac62e5441edc |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-5f96747d50fb4ce6b79dac62e5441edc2025-02-03T01:32:12ZengWileyJournal of Immunology Research2314-88612314-71562015-01-01201510.1155/2015/754825754825Contribution of Genetic Factors to Sjögren’s Syndrome and Sjögren’s Syndrome Related LymphomagenesisAdrianos Nezos0Clio P. Mavragani1Department of Physiology, Medical School, University of Athens, Mikras Asias 75, 11527 Athens, GreeceDepartment of Physiology, Medical School, University of Athens, Mikras Asias 75, 11527 Athens, GreeceWe aimed to summarize the current evidence related to the contributory role of genetic factors in the pathogenesis of Sjögren’s syndrome (SS) and SS-related lymphoma. Genes within the major histocompatibility complex (MHC) locus previously considered conferring increased susceptibility to SS development have been also revealed as important contributors in recent genome wide association studies. Moreover, genetic variations outside the MHC locus involving genes in type I interferon pathway, NF-κB signaling, B- and T-cell function and methylation processes have been shown to be associated with both SS and SS-related lymphoma development. Appreciating the functional implications of SS-related genetic variants could provide further insights into our understanding of SS heterogeneity, allowing the design of tailored therapeutic interventions.http://dx.doi.org/10.1155/2015/754825 |
| spellingShingle | Adrianos Nezos Clio P. Mavragani Contribution of Genetic Factors to Sjögren’s Syndrome and Sjögren’s Syndrome Related Lymphomagenesis Journal of Immunology Research |
| title | Contribution of Genetic Factors to Sjögren’s Syndrome and Sjögren’s Syndrome Related Lymphomagenesis |
| title_full | Contribution of Genetic Factors to Sjögren’s Syndrome and Sjögren’s Syndrome Related Lymphomagenesis |
| title_fullStr | Contribution of Genetic Factors to Sjögren’s Syndrome and Sjögren’s Syndrome Related Lymphomagenesis |
| title_full_unstemmed | Contribution of Genetic Factors to Sjögren’s Syndrome and Sjögren’s Syndrome Related Lymphomagenesis |
| title_short | Contribution of Genetic Factors to Sjögren’s Syndrome and Sjögren’s Syndrome Related Lymphomagenesis |
| title_sort | contribution of genetic factors to sjogren s syndrome and sjogren s syndrome related lymphomagenesis |
| url | http://dx.doi.org/10.1155/2015/754825 |
| work_keys_str_mv | AT adrianosnezos contributionofgeneticfactorstosjogrenssyndromeandsjogrenssyndromerelatedlymphomagenesis AT cliopmavragani contributionofgeneticfactorstosjogrenssyndromeandsjogrenssyndromerelatedlymphomagenesis |