Contribution of Genetic Factors to Sjögren’s Syndrome and Sjögren’s Syndrome Related Lymphomagenesis

We aimed to summarize the current evidence related to the contributory role of genetic factors in the pathogenesis of Sjögren’s syndrome (SS) and SS-related lymphoma. Genes within the major histocompatibility complex (MHC) locus previously considered conferring increased susceptibility to SS develop...

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Main Authors: Adrianos Nezos, Clio P. Mavragani
Format: Article
Language:English
Published: Wiley 2015-01-01
Series:Journal of Immunology Research
Online Access:http://dx.doi.org/10.1155/2015/754825
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author Adrianos Nezos
Clio P. Mavragani
author_facet Adrianos Nezos
Clio P. Mavragani
author_sort Adrianos Nezos
collection DOAJ
description We aimed to summarize the current evidence related to the contributory role of genetic factors in the pathogenesis of Sjögren’s syndrome (SS) and SS-related lymphoma. Genes within the major histocompatibility complex (MHC) locus previously considered conferring increased susceptibility to SS development have been also revealed as important contributors in recent genome wide association studies. Moreover, genetic variations outside the MHC locus involving genes in type I interferon pathway, NF-κB signaling, B- and T-cell function and methylation processes have been shown to be associated with both SS and SS-related lymphoma development. Appreciating the functional implications of SS-related genetic variants could provide further insights into our understanding of SS heterogeneity, allowing the design of tailored therapeutic interventions.
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spelling doaj-art-5f96747d50fb4ce6b79dac62e5441edc2025-02-03T01:32:12ZengWileyJournal of Immunology Research2314-88612314-71562015-01-01201510.1155/2015/754825754825Contribution of Genetic Factors to Sjögren’s Syndrome and Sjögren’s Syndrome Related LymphomagenesisAdrianos Nezos0Clio P. Mavragani1Department of Physiology, Medical School, University of Athens, Mikras Asias 75, 11527 Athens, GreeceDepartment of Physiology, Medical School, University of Athens, Mikras Asias 75, 11527 Athens, GreeceWe aimed to summarize the current evidence related to the contributory role of genetic factors in the pathogenesis of Sjögren’s syndrome (SS) and SS-related lymphoma. Genes within the major histocompatibility complex (MHC) locus previously considered conferring increased susceptibility to SS development have been also revealed as important contributors in recent genome wide association studies. Moreover, genetic variations outside the MHC locus involving genes in type I interferon pathway, NF-κB signaling, B- and T-cell function and methylation processes have been shown to be associated with both SS and SS-related lymphoma development. Appreciating the functional implications of SS-related genetic variants could provide further insights into our understanding of SS heterogeneity, allowing the design of tailored therapeutic interventions.http://dx.doi.org/10.1155/2015/754825
spellingShingle Adrianos Nezos
Clio P. Mavragani
Contribution of Genetic Factors to Sjögren’s Syndrome and Sjögren’s Syndrome Related Lymphomagenesis
Journal of Immunology Research
title Contribution of Genetic Factors to Sjögren’s Syndrome and Sjögren’s Syndrome Related Lymphomagenesis
title_full Contribution of Genetic Factors to Sjögren’s Syndrome and Sjögren’s Syndrome Related Lymphomagenesis
title_fullStr Contribution of Genetic Factors to Sjögren’s Syndrome and Sjögren’s Syndrome Related Lymphomagenesis
title_full_unstemmed Contribution of Genetic Factors to Sjögren’s Syndrome and Sjögren’s Syndrome Related Lymphomagenesis
title_short Contribution of Genetic Factors to Sjögren’s Syndrome and Sjögren’s Syndrome Related Lymphomagenesis
title_sort contribution of genetic factors to sjogren s syndrome and sjogren s syndrome related lymphomagenesis
url http://dx.doi.org/10.1155/2015/754825
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