Blocking YAP1–Liprin-β2 interaction impedes metastasis and promotes tumor suppression in head and neck squamous carcinoma

Blocking YAP1–Liprin-β2 interaction impedes metastasis and promotes tumor suppression in head and neck squamous carcinoma

Abstract Our research investigates the role of the YAP1–PPFIBP2 axis in the epithelial–mesenchymal transition (EMT) and its subsequent impact on invasion and migration in head and neck squamous cell carcinoma (HNSCC). Utilizing both in vitro assays and genomic analyses, we demonstrate that YAP1 upre...

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Main Authors: Seon Rang Woo, Joo Kyung Noh, Min Kyeong Lee, Moonkyoo Kong, Soonki Min, Ji-Youn Sung, Kiyong Na, Suyeon Kang, Junho K. Hur, Seong-Gyu Ko, Young-Gyu Eun
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-11652-0
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https://doi.org/10.1038/s41598-025-11652-0

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