Radiation Quality-Dependent Progressive Increase in Oxidative DNA Damage and Intestinal Tumorigenesis in <i>Apc</i><sup>1638N/+</sup> Mice

Radiation Quality-Dependent Progressive Increase in Oxidative DNA Damage and Intestinal Tumorigenesis in <i>Apc</i><sup>1638N/+</sup> Mice

Exposure to high-linear energy transfer (LET) heavy ions, such as <sup>28</sup>Si, poses a significant cancer risk for astronauts. While previous studies have linked high-LET radiation exposure to persistent oxidative stress and dysregulated stress responses in intestinal crypt cells wit...

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Bibliographic Details
Main Authors: Kamendra Kumar, Santosh Kumar, Jerry Angdisen, Kamal Datta, Albert J. Fornace, Shubhankar Suman
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Current Oncology
Subjects:
ionizing radiation
heavy-ion radiation
8-OxodG
cancer
biomarker
Online Access:https://www.mdpi.com/1718-7729/32/7/382
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