Biotin/sulfasalazine combination therapy alleviates acetic acid-induced ulcerative colitis in rats via modulation of S1PR1/NF-κB/IL-23/STAT3/COX-2 axis

Biotin/sulfasalazine combination therapy alleviates acetic acid-induced ulcerative colitis in rats via modulation of S1PR1/NF-κB/IL-23/STAT3/COX-2 axis

Abstract Ulcerative colitis (UC) is a chronic idiopathic mucosal inflammation of colon. The lack of effective remedies urges us to search for new remedies to effectively cure UC. The current study aims to explore the potential therapeutic effect of sulfasalazine (SLZ)/Biotin combination in ameliorat...

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Bibliographic Details
Main Authors: Sahar A. Helmy, Mahmoud M. Samaha, Al Shaima G. Abd El Salam, Nesma A. Abd Elrazik
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Ulcerative colitis
Sulfasalazine
Biotin
S1PR1
STAT3
IL-23
Online Access:https://doi.org/10.1038/s41598-025-09932-w
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https://doi.org/10.1038/s41598-025-09932-w

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