Sox9 inhibits Activin A to promote biliary maturation and branching morphogenesis

Abstract Intrahepatic bile duct (IHBD) development produces a morphologically heterogeneous network of large “ducts” and small “ductules” by adulthood. IHBD formation is closely linked to developmental specification of biliary epithelial cells (BECs) starting as early as E13.5, but mechanisms regula...

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Bibliographic Details
Main Authors: Hannah R. Hrncir, Brianna Goodloe, Sergei Bombin, Connor B. Hogan, Othmane Jadi, Adam D. Gracz
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-56813-x
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