iPSC-derived cardiomyocytes and engineered heart tissues reveal suppressed JAK2/STAT3 signaling in LMNA-related emery-dreifuss muscular dystrophy

iPSC-derived cardiomyocytes and engineered heart tissues reveal suppressed JAK2/STAT3 signaling in LMNA-related emery-dreifuss muscular dystrophy

LMNA mutation related Emery-Dreifuss muscular dystrophy (LMNA-related EDMD), is a rare genetic disorder often involving life‐threatening cardiac complications. However, the molecular links between LMNA mutations and their related EDMD cardiac phenotypes have remained unclear. Here, using EDMD patien...

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Bibliographic Details
Main Authors: Hangping Fan, Zongkuai Yang, Hangying Ying, Jiuxiao Zhao, Xiaochen Wang, Junhao Gong, Lingying Li, Xujie Liu, Tingyu Gong, Qing Ke, Lenan Zhuang, Ping Liang
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Redox Biology
Subjects:
iPSC-CMs
EHTs
JAK2/STAT3 signaling
lamin A/C
EDMD
ROS
Online Access:http://www.sciencedirect.com/science/article/pii/S221323172500151X
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