Jorunnamycin A induces apoptosis in pancreatic ductal adenocarcinoma cells, spheroids, and patient-derived organoids by modulating KRAS-mediated survival pathways

Jorunnamycin A induces apoptosis in pancreatic ductal adenocarcinoma cells, spheroids, and patient-derived organoids by modulating KRAS-mediated survival pathways

Abstract Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a poor prognosis, frequently driven by oncogenic KRAS mutations. Among these, KRAS G12D is the most prevalent, contributing to chemoresistance and limiting the efficacy of current therapeutic strategies. This study inv...

Full description

Saved in:
Bibliographic Details
Main Authors: Hnin Ei Ei Khine, Utid Suriya, Thanyada Rungrotmongkol, Supakarn Chamni, Yanxi Lu, Alan Bénard, Bin Lan, Debabrata Mukhopadhyay, David Chang, Andrew Biankin, Regine Schneider-Stock, Robert Grützmann, Rungroch Sungthong, Christian Pilarsky, Chatchai Chaotham
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Jorunnamycin A
Pancreatic ductal adenocarcinoma
KRAS mutation
KRAS G12D
Chemotherapy
Chemosensitizer
Online Access:https://doi.org/10.1038/s41598-025-95766-5
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1038/s41598-025-95766-5

Similar Items