Effect of Hepatic Impairment on the Pharmacokinetics of Baicalin in Rats: Critical Roles of Gut Microbiota and Hepatic Transporters

Effect of Hepatic Impairment on the Pharmacokinetics of Baicalin in Rats: Critical Roles of Gut Microbiota and Hepatic Transporters

<b>Background</b>: Baicalin (BG) has been used in the treatment of many diseases. However, the effect of hepatic insufficiency on its pharmacokinetics has not been reported, and there is a lack of clinical guidance for the use of BG in patients with hepatic impairment. <b>Methods&l...

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Main Authors: Ping Li, Yihua Tian, Hong Wang, Yuting Ji, Huiying Zeng, Shengman Zhang, Xiuli Gao, Xiaoyan Chen
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Pharmaceutics
Subjects:
baicalin
hepatic impairment
pharmacokinetics
gut microbiota
hepatic transporters
enterohepatic circulation
Online Access:https://www.mdpi.com/1999-4923/17/7/851
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