Nuclear PHGDH regulates macrophage polarization through transcriptional repression of GLUD1 and GLS2 in breast cancer

Nuclear PHGDH regulates macrophage polarization through transcriptional repression of GLUD1 and GLS2 in breast cancer

Objective: Tumor-associated macrophages (TAMs) exhibit heterogeneous properties including anti-tumorigenic and pro-tumorigenic phenotypes. The rate-limiting enzyme in de novo serine biosynthesis, 3-phosphoglycerate dehydrogenase (PHGDH), has a well-established role in cellular metabolism, yet its sp...

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Bibliographic Details
Main Authors: Pei Wang, Xin Du, Zhiren Han, Jiaxin Zhong, Jiayu Yuan, Lin Jiang, Beinan Han, Wenkui Fu, Hongde Li, Hai Hu, Zhenkun Na
Format: Article
Language:English
Published: China Anti-Cancer Association 2025-05-01
Series:Cancer Biology & Medicine
Subjects:
breast cancer
tumor-associated macrophages
serine metabolism
polarization
Online Access:https://www.cancerbiomed.org/content/22/5/502
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https://www.cancerbiomed.org/content/22/5/502

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