Prevalence of genetic mutations in Alpha-1 antitrypsin in patients with difficult-to-treat asthma in Colombia

Prevalence of genetic mutations in Alpha-1 antitrypsin in patients with difficult-to-treat asthma in Colombia

Abstract Background Alpha-1 antitrypsin (AAT) is a medium-sized globular glycoprotein distributed in serum and tissues. In the lungs, it inhibits serine proteases and has anti-inflammatory properties in different types of cells, protecting lung tissue from damage. Mutations in the SERPINA1 gene that...

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Bibliographic Details
Main Authors: Abraham Alí-Munive, Jaime Leonardo Chacón, Leidy Prada, Nadia Juliana Proaños, Leslie Vargas, Claudia Diaz-Bossa, Angela Giraldo, John Pedrozo-Pupo
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Pulmonary Medicine
Subjects:
Alpha 1- antitrypsin deficiency
Asthma
Genetic mutation
Genotyping test
Epidemiology
Prevalence
Online Access:https://doi.org/10.1186/s12890-025-03840-5
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https://doi.org/10.1186/s12890-025-03840-5

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