HIF‐1α‐induced long noncoding RNA LINC02776 promotes drug resistance of ovarian cancer by increasing polyADP‐ribosylation

HIF‐1α‐induced long noncoding RNA LINC02776 promotes drug resistance of ovarian cancer by increasing polyADP‐ribosylation

Abstract Background Chemoresistance remains a major hurdle in ovarian cancer (OC) treatment, as many patients eventually develop resistance to platinum‐based chemotherapy and/or PARP inhibitors (PARPi). Methods We performed transcriptome‐wide analysis by RNA sequencing (RNA‐seq) data of platinum‐res...

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Main Authors: Yangjun Wu, Yu Zeng, Yong Wu, Xinyu Ha, Zheng Feng, Chaohua Liu, Ziqi Liu, Jiajia Wang, Xingzhu Ju, Shenglin Huang, Linhui Liang, Bin Zheng, Lulu Yang, Jun Wang, Xiaohua Wu, Shengli Li, Hao Wen
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Clinical and Translational Medicine
Subjects:
HIF‐1α
LINC02776
ovarian cancer
PARP1
PARPi resistance
platinum resistance
Online Access:https://doi.org/10.1002/ctm2.70244
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https://doi.org/10.1002/ctm2.70244

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