The Pro12Ala Polymorphism of PPAR-γ Gene Is Associated with Sepsis Disease Severity and Outcome in Chinese Han Population
Peroxisome proliferator-activated receptor-γ (PPAR-γ) is a ligand-binding nuclear receptor, and its activation plays a prominent role in regulating the inflammatory response. Therefore, PPAR-γ has been suggested as a candidate gene for sepsis. In the present study, we investigated the association be...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2014/701971 |
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| author | Guoda Ma Haiyang Wang Guixi Mo Lili Cui You Li Yiming Shao Xin Liu Yuliu Xie Jia Li Jiawu Fu Hua Tao Bin Zhao Liangqing Zhang Keshen Li |
| author_facet | Guoda Ma Haiyang Wang Guixi Mo Lili Cui You Li Yiming Shao Xin Liu Yuliu Xie Jia Li Jiawu Fu Hua Tao Bin Zhao Liangqing Zhang Keshen Li |
| author_sort | Guoda Ma |
| collection | DOAJ |
| description | Peroxisome proliferator-activated receptor-γ (PPAR-γ) is a ligand-binding nuclear receptor, and its activation plays a prominent role in regulating the inflammatory response. Therefore, PPAR-γ has been suggested as a candidate gene for sepsis. In the present study, we investigated the association between the Pro12Ala polymorphism of PPAR-γ and sepsis in a Han Chinese population. A total of 308 patients with sepsis and 345 healthy controls were enrolled in this study. Genotyping was performed using the polymerase chain reaction-ligation detection reaction (PCR-LDR) method. No significant differences were detected in the allele and genotype distributions of the PPAR-γ Pro12Ala SNP between septic patients and controls (P=0.622 for genotype; P=0.629 for allele). However, stratification by subtypes (sepsis, septic shock, and severe sepsis) revealed a statistically significant difference in the frequency of the Ala allele and Ala-carrier genotype between the patients with the sepsis subtype and the healthy controls (P=0.014 for allele and P=0.012, for genotype). Moreover, significant differences were found in the frequency of the Ala allele and genotype between the sepsis survivors and nonsurvivors (all P=0.002). In the survivors, the PPAR-γ Pro12Ala genotype was significantly associated with decreased disease severity and recovery time (all P<0.001). Thus, genetic polymorphism is thought to play a role in the development and outcome of sepsis. |
| format | Article |
| id | doaj-art-5f2ad5274cde48cf969000af1043407d |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-5f2ad5274cde48cf969000af1043407d2025-02-03T06:15:14ZengWileyPPAR Research1687-47571687-47652014-01-01201410.1155/2014/701971701971The Pro12Ala Polymorphism of PPAR-γ Gene Is Associated with Sepsis Disease Severity and Outcome in Chinese Han PopulationGuoda Ma0Haiyang Wang1Guixi Mo2Lili Cui3You Li4Yiming Shao5Xin Liu6Yuliu Xie7Jia Li8Jiawu Fu9Hua Tao10Bin Zhao11Liangqing Zhang12Keshen Li13Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, ChinaDepartment of Vascular Surgery of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, ChinaDepartment of Anesthesiology, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, ChinaGuangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, ChinaGuangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, ChinaIntensive Care Unit, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, ChinaDepartment of Anesthesiology, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, ChinaIntensive Care Unit, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, ChinaIntensive Care Unit, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, ChinaGuangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, ChinaGuangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, ChinaGuangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, ChinaDepartment of Anesthesiology, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, ChinaGuangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, ChinaPeroxisome proliferator-activated receptor-γ (PPAR-γ) is a ligand-binding nuclear receptor, and its activation plays a prominent role in regulating the inflammatory response. Therefore, PPAR-γ has been suggested as a candidate gene for sepsis. In the present study, we investigated the association between the Pro12Ala polymorphism of PPAR-γ and sepsis in a Han Chinese population. A total of 308 patients with sepsis and 345 healthy controls were enrolled in this study. Genotyping was performed using the polymerase chain reaction-ligation detection reaction (PCR-LDR) method. No significant differences were detected in the allele and genotype distributions of the PPAR-γ Pro12Ala SNP between septic patients and controls (P=0.622 for genotype; P=0.629 for allele). However, stratification by subtypes (sepsis, septic shock, and severe sepsis) revealed a statistically significant difference in the frequency of the Ala allele and Ala-carrier genotype between the patients with the sepsis subtype and the healthy controls (P=0.014 for allele and P=0.012, for genotype). Moreover, significant differences were found in the frequency of the Ala allele and genotype between the sepsis survivors and nonsurvivors (all P=0.002). In the survivors, the PPAR-γ Pro12Ala genotype was significantly associated with decreased disease severity and recovery time (all P<0.001). Thus, genetic polymorphism is thought to play a role in the development and outcome of sepsis.http://dx.doi.org/10.1155/2014/701971 |
| spellingShingle | Guoda Ma Haiyang Wang Guixi Mo Lili Cui You Li Yiming Shao Xin Liu Yuliu Xie Jia Li Jiawu Fu Hua Tao Bin Zhao Liangqing Zhang Keshen Li The Pro12Ala Polymorphism of PPAR-γ Gene Is Associated with Sepsis Disease Severity and Outcome in Chinese Han Population PPAR Research |
| title | The Pro12Ala Polymorphism of PPAR-γ Gene Is Associated with Sepsis Disease Severity and Outcome in Chinese Han Population |
| title_full | The Pro12Ala Polymorphism of PPAR-γ Gene Is Associated with Sepsis Disease Severity and Outcome in Chinese Han Population |
| title_fullStr | The Pro12Ala Polymorphism of PPAR-γ Gene Is Associated with Sepsis Disease Severity and Outcome in Chinese Han Population |
| title_full_unstemmed | The Pro12Ala Polymorphism of PPAR-γ Gene Is Associated with Sepsis Disease Severity and Outcome in Chinese Han Population |
| title_short | The Pro12Ala Polymorphism of PPAR-γ Gene Is Associated with Sepsis Disease Severity and Outcome in Chinese Han Population |
| title_sort | pro12ala polymorphism of ppar γ gene is associated with sepsis disease severity and outcome in chinese han population |
| url | http://dx.doi.org/10.1155/2014/701971 |
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