Biochemical analysis of packing and assembling heptad repeat motifs in the coronavirus spike protein trimer

Biochemical analysis of packing and assembling heptad repeat motifs in the coronavirus spike protein trimer

ABSTRACT During a coronavirus infection, the spike protein undergoes sequential structural transitions triggered by its receptor and the host protease at the interface between the virus and cell membranes, thereby mediating membrane fusion. After receptor binding, the heptad repeat motif (HR1/HR2) w...

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Bibliographic Details
Main Authors: Jun Kobayashi, Kazuhiko Kanou, Hiyori Okura, Tahmina MST Akter, Shuetsu Fukushi, Shutoku Matsuyama
Format: Article
Language:English
Published: American Society for Microbiology 2024-11-01
Series:mBio
Subjects:
coronavius
spike
fusion
protease
CEACAM1a
ACE2
Online Access:https://journals.asm.org/doi/10.1128/mbio.01203-24
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https://journals.asm.org/doi/10.1128/mbio.01203-24

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