A novel hybrid approach to overcome defects of CE-SELEX and cell-SELEX in developing aptamers against aspartate β-hydroxylase

A novel hybrid approach to overcome defects of CE-SELEX and cell-SELEX in developing aptamers against aspartate β-hydroxylase

Background and purpose: Aptamers, a new category of molecular probes, are overthrowing antibodies in molecular diagnostics. However, there are serious problems with using aptamers for this application including poor or non-specific binding in vivo conditions. Systematic evolution of aptamers is achi...

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Bibliographic Details
Main Authors: Hadi Bakhtiari, Hamed Naghoosi, Sina Sattari, Mahmoud Vahidi, Mehdi Shakouri Khomartash, Ali Faridfar, Mohsen Rajaeinejad, Mohsen Nikandish
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2025-01-01
Series:Research in Pharmaceutical Sciences
Subjects:
aptamers
aspartate β-hydroxylase
capillary electrophoresis
high-throughput nucleotide sequencing
selex aptamer technique
Online Access:https://journals.lww.com/10.4103/RPS.RPS_134_23
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https://journals.lww.com/10.4103/RPS.RPS_134_23

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