Reporters to mark and eliminate basal or luminal epithelial cells in culture and in vivo.

Reporters to mark and eliminate basal or luminal epithelial cells in culture and in vivo.

The contribution of basal and luminal cells to cancer progression and metastasis is poorly understood. We report generation of reporter systems driven by either keratin-14 (K14) or keratin-8 (K8) promoter that not only express a fluorescent protein but also an inducible suicide gene. Transgenic mice...

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Main Authors: Olmo Sonzogni, Jennifer Haynes, Laurie A Seifried, Yahia M Kamel, Kai Huang, Michael D BeGora, Faith Au Yeung, Celine Robert-Tissot, Yujing J Heng, Xin Yuan, Gerbug M Wulf, Ken J Kron, Elvin Wagenblast, Mathieu Lupien, Thomas Kislinger, Gregory J Hannon, Senthil K Muthuswamy
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-06-01
Series:PLoS Biology
Online Access:https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.2004049&type=printable
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https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.2004049&type=printable

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