Aging-dependent YAP1 reduction contributes to AD pathology by upregulating the Nr4a1-AKT/GSK-3β axis

Aging-dependent YAP1 reduction contributes to AD pathology by upregulating the Nr4a1-AKT/GSK-3β axis

Abstract Background Aging is the greatest risk factor for late-onset Alzheimer’s disease (LOAD), which accounts for > 95% of all Alzheimer’s disease (AD) cases. Yes-associated protein 1 (YAP1), an aging-dependent protein, is a key element in the classical Hippo-YAP1 pathway mediated by a kinase c...

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Bibliographic Details
Main Authors: Ling Lei, Yilei Cheng, Anqi Yin, Jian-Min Han, Gang Wu, Fumin Yang, Qi Wang, Jian-Zhi Wang, Rong Liu, Hong-Lian Li, Xiaochuan Wang
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Translational Neurodegeneration
Subjects:
YAP1
Nr4a1
Alzheimer’s disease
Senescence
Online Access:https://doi.org/10.1186/s40035-025-00487-4
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https://doi.org/10.1186/s40035-025-00487-4

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