Allopurinol attenuates development of Porphyromonas gingivalis LPS-induced cardiomyopathy in mice.

Allopurinol attenuates development of Porphyromonas gingivalis LPS-induced cardiomyopathy in mice.

Oxidative stress is involved in the progression of periodontitis, independently of confounding factors such as smoking, and numerous studies suggest that periodontitis is associated with increased risk of cardiovascular disease. In this study, therefore, we examined the effects of the xanthine oxida...

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Main Authors: Akinaka Morii, Ichiro Matsuo, Kenji Suita, Yoshiki Ohnuki, Misao Ishikawa, Aiko Ito, Go Miyamoto, Mariko Abe, Takao Mitsubayashi, Yasumasa Mototani, Megumi Nariyama, Ren Matsubara, Yoshio Hayakawa, Yasuharu Amitani, Kazuhiro Gomi, Takatoshi Nagano, Satoshi Okumura
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0318008
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https://doi.org/10.1371/journal.pone.0318008

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