Genome-wide CRISPR Screening Identifies NFκB and c-MET as Druggable Targets to Sensitize Lenvatinib Treatment in Hepatocellular CarcinomaSummary

Background & Aims: Hepatocellular carcinoma (HCC), the dominant form of liver cancer, is a leading cause of cancer death worldwide. Sorafenib and lenvatinib have long been the 2 limited options of first-line treatments for patients with unresectable advanced HCC. However, the single-drug tre...

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Main Authors: Ting-Chi Rebecca Wan, Lai Wei, Lai-Hung Cheng, Wai-Ching Chin, Jialing Shen, For-Fan Chan, Zhijian Kuang, Cun Wang, Carmen Chak-Lui Wong, Chun-Ming Wong
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
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Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X25000438
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