Pharmacological Enhancement of Adult Hippocampal Neurogenesis Improves Behavioral Pattern Separation in Young and Aged Male Mice

Pharmacological Enhancement of Adult Hippocampal Neurogenesis Improves Behavioral Pattern Separation in Young and Aged Male Mice

Background: Impairments in behavioral pattern separation (BPS)—the ability to distinguish between similar contexts or experiences—contribute to memory interference and overgeneralization seen in many neuropsychiatric conditions, including depression, anxiety, posttraumatic stress disorder, dementia,...

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Main Authors: Wei-li Chang, Karly Tegang, Benjamin A. Samuels, Michael Saxe, Juergen Wichmann, Denis J. David, Indira Mendez David, Angélique Augustin, Holger Fischer, Sabrina Golling, Jens Lamerz, Doris Roth, Martin Graf, Sannah Zoffmann, Luca Santarelli, Ravi Jagasia, René Hen
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Biological Psychiatry Global Open Science
Subjects:
Aging
Dentate gyrus
Drug development
Hippocampal neurogenesis
Neurogenic compounds
Pattern separation
Online Access:http://www.sciencedirect.com/science/article/pii/S2667174324001320
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